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These cells often fail to grow out after monoclonal isolation using flow sorting. In the few months since adopting the CellRaft, we have isolated thousands of validated monoclonals from elephants, canids and deer with consistent outgrowth efficiencies." See Colossal’s Innovative Research in Reviving Extinct Species like the Woolly Mammoth. See it on CNN. Dr. Sven Bocklandt Species Director at Colossal where he is leading a team of genome engineers and cell biologists focused on bringing back extinct animal species. "We can now easily identify thousands of single organoids with various morphologies (size, shape, complexity) and isolate hundreds in less than an hour. We also use the CellRaft AIR System for cloning of transgenic or CRISPR-edited human intestinal stem cells. Prior to the air system, the efficiency of isolating clonal lines was very inefficient because of the low throughput. Now we can isolate hundreds or thousands of clonal organoids in an unprecedented short amount of time compared to before. " Scott Magness, Ph.D. Associate Professor, University of North Carolina – Chapel Hill, NC State University Joint Departments of Biomedical Engineering, UNC Departments of Medicine, Cell Biology, & Physiology "Several adherent lines tested in the lab do not survive sorting at high pressure and their outgrowth is poor when sorted singly in plates. Manually limiting dilution was previously the only process for obtaining clones; however, we can now utilize the CellRaft AIR® system for adherent lines as well." Download Poster "We recommend the CellRaft Technology for our colleagues struggling with single cell isolation. Even with help from FACS, although single cell clones could be obtained, from our experiences, CellRaft not only speeds up this process by providing many more clones but more importantly, the unique monitoring process provided by CellRaft supplies additional information for every single clone with a higher quality of clones ." Pengda Liu Associate Professor of Biochemistry and Biophysics / Lineberger Comprehensive Cancer Center / The University of North Carolina at Chapel Hill We are the cell engineering group that provides engineered cancer cell lines for cell-based assays to groups across the organization. We have purchased a second CellRaft AIR for our operations as CellRaft AIR has replaced limiting dilution and, to some extent, flow sorting in our workflow. Our workflow demands engineered cells that need to be developed into monoclonal colonies. A huge advantage for us is the ability to track and trace monoclonality via imaging. I am glad that the response from Cell Microsystems has always been fast in supporting our usage and adoption of the system. The switch to Cellraft Arrays has resulted in a dramatic decrease in reagent usage while increasing our productivity by 2 to 3 fold” Director of Cell Engineering and Development Top 10 Global Biopharma Organization in New York City We employed the CellRaft Technology to help isolate clones derived from verified single cells in a cell line that was very difficult to clone by regular limiting dilution. It worked beautifully, producing clones with sequencing-verified distinct genotypes quite easily. This technology is definitely a big advance for anyone trying to isolate clones from single cells!!” W. Brian Dalton, M.D., Ph.D. Assistant Professor of Oncology, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center Our work routinely involves knocking in two or more unrelated fluorescent proteins into a single cell line by lentiviral methods. A significant challenge has been the isolation of strongly expressing all-positive clones for use as reporters. A more facile approach to knocking in and isolating such clones would greatly accelerate our work over engineering alternative construct designs. Cell Microsystems was able to isolate clones of THP-1 monocytes that are highly fluorescent for our assays. I would recommend this technology (CellRaft Technology) as a viable alternative to FACS, especially when cell populations are limiting.” Gregory Poon, Ph.D., B.Sc.Phm. Professor of Chemistry, Georgia State University Unique and Cutting-edge Tools to Advance Your Research Advance Your Research Cell Line, Clone, & Organoid Growth and Isolation System The CellRaft AIR® System is an integrated platform that uses proprietary technology to maintain cells in an unperturbed state, leading to improved viability of single cells , highly proliferative colonies, and superior clonal outgrowth, which provides a dramatic increase in the number of clones available for downstream applications. With the system, you can: Obtain 10 – 50X more viable monoclonal colonies. Grow single cells in a flask-like environment, without physically separating them. Identify cells of interest using powerful, label-free brightfield or fluorescence analysis software with user-defined parameters. Automatically and gently isolate CellRafts containing cells or colonies of interest for downstream endpoint analysis or clonal expansion. Discover CellRaft AIR System Get started with Immune Profiling Core Shear Flow System The BioFlux Systems offer you the ability to introduce physiological shear flow to your research and drug discovery experiments, effectively emulating in vivo conditions and revealing the true biology. Bridge the gap between in vitro and in vivo experiments with controlled shear flow between 0-200 dyn/cm². Achieve high throughput with up to 96 flow cell assays run in...